Proper balance between the biogenesis and degradation of cellular proteins is critical for the regulation of nearly all biochemical processes. A lapse in cellular protein homeostasis (proteostasis) has recently emerged as a common mechanism in the molecular basis of a wide variety of diseases. Using various biochemical techniques, our lab seeks fundamental insights into the physiochemical reactions that govern the proteostasis of integral membrane proteins, and how failure of these processes give rise to diseases states. We also endeavor to utilize new insights and methodological advances to address emerging challenges in precision medicine.
Cotranslational Misfolding and Integral Membrane Proteostasis
Deep Mutational Scanning of Disease-Linked Membrane Proteins
Impact of Mutations on Membrane Protein Folding
Impact of Cotranslational Folding on Programed Ribosomal Frameshifting