27
Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning

Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning

Andrew G. McKee, Charles P. Kuntz, Joseph T. Ortega, Hope Woods, Francis J. Roushar, Jens Meiler, Beata Jastrzebska, and Jonathan P. Schlebach bioRxiv (2021) doi: https://doi.org/10.1101/2021.03.26.437229 https://www.biorxiv.org/content/10.1101/2021.03.26.437229v1
26
Coordination of -1 Programmed Ribosomal Frameshifting by Transcript and Nascent Chain Features Revealed by Deep Mutational Scanning

Coordination of -1 Programmed Ribosomal Frameshifting by Transcript and Nascent Chain Features Revealed by Deep Mutational Scanning

Patrick J. Carmody, Matthew H. Zimmer, Charles P. Kuntz, Haley R. Harrington, Kate E. Duckworth, Wesley D. Penn, Suchetana Mukhopadhyay, Thomas F. Miller III, Jonathan P. Schlebach bioRxiv (2021) doi: https://doi.org/10.1101/2021.03.11.435011 https://www.biorxiv.org/content/10.1101/2021.03.11.435011v1
25
Disease-Linked Super-Trafficking of a Potassium Channel

Disease-Linked Super-Trafficking of a Potassium Channel

Hui Huang, Laura M. Chamness, Carlos G. Vanoye, Georg Kuenze, Jens Meiler, Alfred L George Jr., Jonathan P. Schlebach, Charles R. Sanders Journal of Biological Chemistry (2020) 296, 100423. https://www.jbc.org/article/S0021-9258(21)00196-4/fulltext
24
A Protein Folding Intermediate Pulls Its Weight

A Protein Folding Intermediate Pulls Its Weight

Jonathan P. Schlebach Journal of Biological Chemistry (2020) 295, 11418-11419. https://www.jbc.org/article/S0021-9258(17)48447-X/fulltext
23
Regulators of Viral Frameshifting: More Than RNA Influences Translation Events.

Regulators of Viral Frameshifting: More Than RNA Influences Translation Events.

Wesley D. Penn, Haley R. Harrington, Jonathan P. Schlebach, and Suchetana Mukhopadhyay Annual Review of Virology (2020) 7, 219-238. https://www.annualreviews.org/doi/abs/10.1146/annurev-virology-012120-101548
22
Classification of the Molecular Defects Associated with Pathogenic Variants of the SLC6A8 Creatine Transporter

Classification of the Molecular Defects Associated with Pathogenic Variants of the SLC6A8 Creatine Transporter

Martin Salazar, Nathan B. Zelt, Robert Saldivar, Charles P. Kuntz, Sheng Chen, Wesley D. Penn, Richard Bonneau, Julia Koehler Leman, and Jonathan P. Schlebach Biochemistry (2020) 59, 1367-1377. https://pubs.acs.org/doi/abs/10.1021/acs.biochem.9b00956
21
Cotranslational Folding Stimulates Programmed Ribosomal Frameshifting in the Alphavirus Structural Polyprotein

Cotranslational Folding Stimulates Programmed Ribosomal Frameshifting in the Alphavirus Structural Polyprotein

Haley R. Harrington, Matthew H. Zimmer, Laura M. Chamness, Veronica Nash, Wesley D. Penn, Thomas F Miller III, Suchetana Mukhopadhyay, and Jonathan Patrick Schlebach Journal of Biological Chemistry (2020) 295, 6798-6808. *Editors Pick, selected for the cover https://www.jbc.org/content/295/20/6798.short
20
Probing Biophysical Sequence Constraints within the Transmembrane Domains of Rhodopsin by Deep Mutational Scanning

Probing Biophysical Sequence Constraints within the Transmembrane Domains of Rhodopsin by Deep Mutational Scanning

Wesley D. Penn, Andrew McKee, Charles P. Kuntz, Hope Woods, Veronica Nash,Timothy C. Gruenhagen, Francis J. Roushar, Mahesh Chandak, Chris Hemmerich, Douglas B. Rusch, Jens Meiler  & Jonathan P. Schlebach Science Advances (2020) 6, eaay7505. https://advances.sciencemag.org/content/6/10/eaay7505
19
Molecular Basis for the Evolved Instability of a Human G-Protein Coupled Receptor

Molecular Basis for the Evolved Instability of a Human G-Protein Coupled Receptor

Laura M. ChamnessNathan B. ZeltCharles P. KuntzBrian J. BenderWesley D. PennJoshua J. ZiarekJens Meiler & Jonathan P. Schlebach bioRxiv (2019) doi: https://doi.org/10.1101/2019.12.20.884718 https://www.biorxiv.org/content/10.1101/2019.12.20.884718v1
18
Ions at the Interface: Pushing the pK of pHLIP

Ions at the Interface: Pushing the pK of pHLIP

Jonathan P. Schlebach Biophysical Journal (2019) 117, 793-794. https://www.cell.com/biophysj/fulltext/S0006-3495(19)30624-1
17
Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis

Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis

Justin T. Marinko, Hui Huang, Wesley D. Penn, Anthony J. Capra, Jonathan P. Schlebach & Charles R. Sanders Chemical Reviews (2019) 119, 5537-5606.  https://pubs.acs.org/doi/10.1021/acs.chemrev.8b00532
16
Contribution of Cotranslational Folding Defects to Membrane Protein Homeostasis

Contribution of Cotranslational Folding Defects to Membrane Protein Homeostasis

Francis J. Roushar, Timothy C. Gruenhagen, Wesley D. Penn, Bian Li, Jens Meiler, Beata Jastrzebska & Jonathan P. Schlebach Journal of the Americal Chemical Society (2019) 141, 204-215. https://pubs.acs.org/doi/10.1021/jacs.8b08243
15
The Retinitis Pigmentosa-Linked Mutations in Transmembrane Helix 5 of Rhodopsin Disrupt Cellular Trafficking Regardless of Oligomerization State

The Retinitis Pigmentosa-Linked Mutations in Transmembrane Helix 5 of Rhodopsin Disrupt Cellular Trafficking Regardless of Oligomerization State

D. Paul Mallory, Elizabeth Gutierrez, Mararet Pinkevitch, Christie Klinginsmith, William D. Comar, Francis J. Roushar, Jonathan P. Schlebach, Adam W. Smith & Beata Jastrzebska Biochemistry (2018) 57, 5188-5201.  https://pubs.acs.org/doi/10.1021/acs.biochem.8b00403
14
Bicelle size modulates the rate of bacteriorhodopsin folding

Bicelle size modulates the rate of bacteriorhodopsin folding

Timothy C. Gruenhagen, Joshua J. Ziarek & Jonathan P. Schlebach Protein Science (2018) 27, 1109-1112. https://onlinelibrary.wiley.com/doi/full/10.1002/pro.3414
13
Peripheral myelin protein 22 alters membrane architecture

Peripheral myelin protein 22 alters membrane architecture

Kathleen F. Mittendorf, Justin T. Marinko, Cheri M. Hampton, Zunlong Ke, Arina Hadziselimovic, Jonathan P. Schlebach, Cheryl L. Law, Jun Li, Elizabeth R. Wright, Charles R. Sanders & Melanie D. Ohi Science Advances (2017) 3, e1700220. https://advances.sciencemag.org/content/3/7/e1700220
12
A pH-Mediated Conformational Switch within the N-terminal Domain of Human Caveolin-3

A pH-Mediated Conformational Switch within the N-terminal Domain of Human Caveolin-3

JiHun Kim, Jonathan P. Schlebach, Zhenwei Lu, Dungeng Peng, Kaitlyn C. Reasoner & Charles R. Sanders Biophysical Journal (2016) 110, 2475-2485. https://www.cell.com/biophysj/fulltext/S0006-3495(16)30280-6
11
Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles

Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles

Jonathan P. Schlebach, Paul J. Barrett, Charles A. Day, JiHun Kim, Anne K. Kenworthy & Charles R. Sanders Biochemistry (2016) 55, 985-988. https://pubs.acs.org/doi/full/10.1021/acs.biochem.5b01154
10
Conformational Stability and Pathogenic Misfolding of the Integral Membrane Protein PMP22

Conformational Stability and Pathogenic Misfolding of the Integral Membrane Protein PMP22

Jonathan P. Schlebach, Malathi Narayan, Catherine Alford, Kathleen F. Mittendorf, Bruce D. Carter, Jun Li & Charles R. Sanders Journal of the American Chemical Society (2015) 137, 8758-8768. https://pubs.acs.org/doi/10.1021/jacs.5b03743
9
The Safety Dance: Biophysics of Membrane Protein Folding and Misfolding in a Cellular Context

The Safety Dance: Biophysics of Membrane Protein Folding and Misfolding in a Cellular Context

Jonathan P. Schlebach & Charles R. Sanders Quarterly Reviews of Biophysics (2015) 48, 1-34. https://www.cambridge.org/core/journals/quarterly-reviews-of-biophysics/article/safety-dance-biophysics-of-membrane-protein-folding-and-misfolding-in-a-cellular-context/CB389744277F67C0729F54B08A9B1FB2
8
Bacteriorhodopsin Folds through a Poorly Ordered Transition State

Bacteriorhodopsin Folds through a Poorly Ordered Transition State

Jonathan P. Schlebach,* Nicholas Woodall,* James U. Bowie & Chiwook Park. Journal of the American Chemical Society (2014) 136, 16574-165881. https://pubs.acs.org/doi/full/10.1021/ja508359n   *Authors contributed equally.
7
Influence of Pathogenic Mutations on the Energetics of Translocon-Mediated Bilayer Integration of Transmembrane Helices

Influence of Pathogenic Mutations on the Energetics of Translocon-Mediated Bilayer Integration of Transmembrane Helices

Jonathan P. Schlebach & Charles R. Sanders Journal of Membrane Biology (2014) 248, 371-381. https://link.springer.com/article/10.1007%2Fs00232-014-9726-0
6
Modest Effects of Lipid Modifications on the Structure of Caveolin-3

Modest Effects of Lipid Modifications on the Structure of Caveolin-3

JiHun Kim, Dungeng Peng, Jonathan P. Schlebach & Charles R. Sanders Biochemistry (2014) 53, 4320-4322. https://pubs.acs.org/doi/10.1021/bi5005238
5
Reversible Folding of Human Peripheral Myelin Protein 22, a Tetraspan Membrane Protein

Reversible Folding of Human Peripheral Myelin Protein 22, a Tetraspan Membrane Protein

Jonathan P. Schlebach, Dungeng Peng, Kathleen F. Mittendorf, Malathi Narayan, Bruce D. Carter & Charles R. Sanders Biochemistry (2013) 52, 3229-3241. https://pubs.acs.org/doi/full/10.1021/bi301635f
4
A Simplified Proteomics Approach to Discover Protein-Ligand Interactions

A Simplified Proteomics Approach to Discover Protein-Ligand Interactions

Youngil Chang, Jonathan P. Schlebach, Ross Verheul & Chiwook Park Protein Science (2012) 21, 1280-1287. https://onlinelibrary.wiley.com/doi/full/10.1002/pro.2112  
3
Revisiting the Folding Kinetics of Bacteriorhodopsin

Revisiting the Folding Kinetics of Bacteriorhodopsin

Jonathan P. Schlebach, Zheng Cao, James U. Bowie & Chiwook Park Protein Science (2012) 21, 97-106. https://onlinelibrary.wiley.com/doi/full/10.1002/pro.766  
2
Thermodynamic Stability of Bacteriorhodopsin Mutants Measured Relative to the Bacterioopsin Unfolded State

Thermodynamic Stability of Bacteriorhodopsin Mutants Measured Relative to the Bacterioopsin Unfolded State

Zheng Cao, Jonathan P. Schlebach, Chiwook Park & James Bowie Biochimica et Biophysica Acta Biomembranes (2012) 1818, 1049-1054. https://www.sciencedirect.com/science/article/pii/S0005273611002811?via%3Dihub
1
Probing Membrane Protein Unfolding by Pulse Proteolysis

Probing Membrane Protein Unfolding by Pulse Proteolysis

Jonathan P. Schlebach, Moon-Soo Kim, Nathan Joh, James Bowie & Chiwook Park Journal of Molecular Biology (2011), 406, 545-551.https://www.sciencedirect.com/science/article/abs/pii/S0022283610013252?via%3Dihub